Cilia beating of ependymal cells maintains adult neural stem cell quiescence through PKD1/2-TRPM3-mediated mechanical forces, with brief inhibition activating stem cells in vivo.
- 2 cites
Genetic and Kidney Cyst Diseases
Moving in Neuron.
- Moved this week
- 1
Rebuilt
Moved this week
Latest in Genetic and Kidney Cyst Diseases
Newest first · last 60 days
Ciliopathy iPSC-derived RPE uniformly exhibit mesenchymal drift driven by TGF-β signaling, revealing a common pathogenic cell state across diverse genetic mutations.
- Open access
OCRL deficiency in Lowe syndrome causes mitochondrial dysfunction, impaired cilia-related Sonic Hedgehog signaling, and disrupted neuronal differentiation across multiple models.
- Open access
Cilia beating of ependymal cells maintains adult neural stem cell quiescence through PKD1/2-TRPM3-mediated mechanical forces, with brief inhibition activating stem cells in vivo.
- 2 cites
Disruption of basal body docking causes centriole clustering and elimination, leading to male infertility in mammalian spermatogenesis, with 100% of affected cells showing these defects.
- Open access
Amygdala astrocyte primary cilia disruption during stress impairs behavior, but restoring cilia improves stress responses and molecular markers.
- Open access
GRAF1-dependent endocytotic processes and the Golgi apparatus jointly facilitate early stages of ciliogenesis, revealing new intermediate structures in cilia assembly.
- Open access
Cryo-electron microscopy reveals NHE6 as a homodimer with lipid-dependent regulation, crucial for endosomal pH control, with structures at 2.2–3.3 Å resolution.
- Open access
Bi-allelic loss-of-function variants in CDK20 cause a severe ciliopathy with midline brain and facial anomalies in seven individuals from five families.
Functional validation confirms the PKD1 c.7489 + 5G>A variant causes pathogenic exon skipping in an ADPKD family, enabling successful prevention of disease transmission.
- Open access
Follow this area in the app
Browse JClub
Journals this month
- bioRxiv5569
- medRxiv1746
- Environ Res483
- PNAS463
- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ199
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4