The abstract is read at the publisher; the summary is JClub's.
Ciliated keratinocytes are largely restricted to atopic dermatitis and psoriatic skin (pre and post phototherapy), where they account for >70% of ciliated cells and form a basal/spinous inflammatory niche.
- Why it matters: Psoriasis vulgaris and atopic dermatitis flare repeatedly and do not fully resolve, but the molecular identity and clinical relevance of rare epidermal ciliated cells are unclear.
- What they did: Single-cell-resolved spatial transcriptomics plus primary cilia immunostaining were integrated in healthy skin (n=6), AD lesions (n=10), and paired psoriatic skin before/after phototherapy (n=7 each), with HaCaT functional tests using MAPK/NFkB assays, ATAC-seq, and pathway inhibition.
- The result: Increased primary cilia formation enhanced MAPK and NFkB signaling and primed inflammatory chromatin accessibility at AP1-enriched loci; ERK1/2 inhibition reduced cytokine-induced cilia formation, and higher residual ciliated KC abundance after phototherapy predicted subsequent treatment escalation.
The findingWhy it mattersWhat they didThe result
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