Meningeal macrophages refine dorsal meningeal lymphatic development, influencing social behavior and potentially contributing to autism spectrum disorder.
- Open access
- 3 cites
Cerebrospinal fluid and hydrocephalus
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Osteoclasts disrupt meningeal lymphatic drainage in dural metastasis, with significant impairment linked to tumor progression in a mouse model.
- 1 cites
Ciliopathy iPSC-derived RPE uniformly exhibit mesenchymal drift driven by TGF-β signaling, revealing a common pathogenic cell state across diverse genetic mutations.
- Open access
Cochlin, an extracellular matrix protein, enhances brain immune defense by reducing bacterial load, with levels increasing during infection in zebrafish, mice, and humans.
- Open access
Arachnoid fenestrations around the olfactory bulbs enable CSF clearance via dural lymphatics, with 20-50% of tracers passing through these openings in mice and monkeys.
Molecular regulators and cell interactions make the blood-brain barrier a dynamic, highly selective interface crucial for CNS health and disease.
- 5 cites
Amygdala astrocyte primary cilia disruption during stress impairs behavior, but restoring cilia improves stress responses and molecular markers.
- Open access
Meningeal macrophages refine dorsal meningeal lymphatic development, influencing social behavior and potentially contributing to autism spectrum disorder.
- Open access
- 3 cites
Brain capillary endothelial cells autonomously repair injury through VEGFR2-dependent membrane extension, restoring blood flow within 24-48 hours in mice.
- Open access
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