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Three-dimensional T1 mapping demonstrates the transfer of oxygen into cerebrospinal fluid during hyperoxia
bioRxiv · · Preprint · Open access
Biondetti, Di Censo + 11 more
Abstract ↗AI summary
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In 29 healthy subjects at 3T, 100% hyperoxia produces significant, region-dependent CSF T1 reductions, stabilizing between 7 and 10 minutes in cortical subarachnoid space and basilar cisterns.
- Why it matters: Blood-to-CSF oxygen exchange is poorly characterized across the whole brain, and a non-invasive way to track its regional dynamics could help assess vessel-wall oxygen permeability.
- What they did: The authors optimized non-invasive 3D SPACE T1 mapping, using high-resolution 0.9-mm isotropic scans (~16 minutes) and faster 3-mm isotropic repeats (~3.5 minutes) during 100% hyperoxia.
- The result: Oxygen-related T1 decreases were most prominent and rapid in cortical subarachnoid space and basilar cisterns, with smaller high-resolution-only changes in posterior lateral ventricles and cisterna magna over ~16 minutes.
The findingWhy it mattersWhat they didThe result
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