The abstract is read at the publisher; the summary is JClub's.
In postmortem human choroid plexus, nodular stromal fibrosis is negatively associated with large lipid droplets in choroid plexus epithelial cells, with fewer lipid-droplet–positive cells in more-fibrotic individuals.
- Why it matters: Fibrosis is an age-related change that likely impairs choroid plexus function, but its cellular links to lipid storage and homeostasis were unclear.
- What they did: The study annotated fibrosis in 81 atrial choroid plexus specimens and trained a deep learning model on hematoxylin and eosin whole-slide images from 204 cases to stage dense, hyalinized, and mineralized fibrosis.
- The result: A second deep learning model showed CPECs near fibrotic papillae were less likely to contain large lipid droplets, with negative correlations across papillae and fewer such CPECs in individuals with more nodular fibrosis.
The findingWhy it mattersWhat they didThe result
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