Plakophilin 1 (PKP1) suppresses keratinocyte innate immune responses by sequestering RNA helicases, preventing excessive inflammation in healthy skin cells.
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Hair Growth and Disorders
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A four-dimensional molecular map of hair follicle organogenesis reveals dynamic developmental processes in neonatal mouse skin.
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Coordination of extra-embryonic cells alone can recreate human primitive streak formation, revealing a key role in early gastrulation with extended developmental potential.
Chemically induced skin tumors mainly originate from Lgr6+ and Lrig1+ stem cells in the upper hair follicle, with fewer arising from other hair follicle populations.
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