CDK2 inhibitors induce RB-independent tumor suppression in CDK4/6 inhibitor-resistant HR+/HER2- breast cancer, with disease stabilization observed in patients.
- Open access
HER2/EGFR in Cancer Research
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Modular in vivo antibody-ADC click strategy enhances tumor targeting and overcomes resistance in heterogeneous cancers, showing improved activity in preclinical models.
- Open access
IL1RAP antibody-drug conjugates effectively target primary and metastatic tumors in multiple oncofusion-driven cancers, causing tumor regression and reducing metastasis.
- Open access
- 1 cites
Sunvozertinib significantly improves progression-free survival compared to chemotherapy as a first-line treatment for NSCLC with EGFR exon 20 insertions, with a median of 10.3 versus 7.5 months.
- 1 cites
Targeted KRASG12V degradation causes rapid lung adenocarcinoma regression in mice, but resistance develops due to dysregulated proteolysis, highlighting a new therapeutic avenue.
- Open access
- 1 cites
Adjacent cancer cells produce GABA that suppresses TLS function, contributing to immunotherapy resistance in tumors with tertiary lymphoid structures.
Fulvestrant-induced iPhase-CAR T cells achieve precise, reversible control of antitumor activity, enhancing efficacy while minimizing side effects.
Mosunetuzumab plus polatuzumab vedotin achieved an 88.1% objective response rate in heavily pretreated relapsed/refractory mantle cell lymphoma patients, including high-risk groups.
- Open access
- 5 cites
A specific gene expression signature predicts improved survival with bevacizumab in ovarian cancer patients, with overexpression linked to a hazard ratio of 0.41.
- Open access
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