Research area · week to 3 Oct 2026

Esophageal Cancer Research and Treatment

Moving in Gastroenterology, Gut, Nature Medicine, Cancer Cell, JAMA, medRxiv, Molecular therapy. Nucleic acids, The American Journal of Human Genetics.

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Latest in Esophageal Cancer Research and Treatment

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Non-Endoscopic Screening for Barretts Esophagus Using a DNA Methylation-Based Assay: Real-World Experience in 11,991 Patients
medRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.20.25340693
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Long-Term Follow-Up From the Barrett's Esophagus Screening Trial 3 Demonstrates High Negative Predictive Value of Capsule Sponge-Trefoil Factor 3 Test for Esophageal Adenocarcinoma.
Gastroenterology · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42448239
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Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma.
The American Journal of Human Genetics · 23 Sept 2026 · Expression of Concern
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https://jclub.com.au/a/42808262
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Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence.
Nature Medicine · 22 Sept 2026 · Journal Article
EAGLE AI model detects early esophageal cancer with 90% sensitivity and 98.5% specificity from chest CT scans across multiple centers, enabling scalable screening.
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https://jclub.com.au/a/42773211
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Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC.
Gut · 18 Sept 2026 · Journal Article
Coordinated cellular programmes involving exhausted T cells, regulatory T cells, memory B cells, and macrophages predict responses to neoadjuvant PD-L1 blockade in ESCC.
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https://jclub.com.au/a/42760117
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Liquid biopsy for early detection of pancreatic ductal adenocarcinoma.
Nature Medicine · 16 Sept 2026 · Journal Article
A blood-based microRNA assay combined with carbohydrate antigen 19-9 detects early-stage pancreatic ductal adenocarcinoma with 86.8% sensitivity in a large international study.
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https://jclub.com.au/a/42749887
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Response to: 'Rectal versus colonic submucosal cancer rates and procedural outcomes in large non-pedunculated polyps: French ESD registry data' by Van der Voort et al.
Gut · 7 Sept 2026 · Letter
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https://jclub.com.au/a/41314787
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Surgical and Endoscopic Therapies for GERD.
JAMA · 1 Sept 2026 · Journal Article
Surgical and endoscopic therapies, including radiofrequency, plication, and mucosal resection, offer diverse options for treating GERD patients.
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https://jclub.com.au/a/42384419
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Achalasia and Risk of Esophageal Squamous Cell Carcinoma and Adenocarcinoma in a Multinational Study.
Gastroenterology · 1 Sept 2026 · Multicenter Study
Achalasia is strongly linked to esophageal squamous cell carcinoma, with an odds ratio of 9.46, but its connection to adenocarcinoma is weaker and largely explained by GERD.
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https://jclub.com.au/a/42019768
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miRNA-34a-5p is a novel biomarker and modulator of the radioresponse in esophageal adenocarcinoma.
Molecular therapy. Nucleic acids · 18 Aug 2026 · Journal Article
miR-34a-5p acts as a radiosensitizer and biomarker, with reduced expression linked to poor treatment response and survival in esophageal adenocarcinoma.
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https://jclub.com.au/a/42732218
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Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia.
Cancer Cell · 10 Aug 2026 · Expression of Concern
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https://jclub.com.au/a/42773983
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Ten-Year Follow-Up After Endoscopic Submucosal Dissection for Clinical T1a Undifferentiated-Type Early Gastric Cancer ≤2 cm Without Ulceration in a Nonrandomized, Single-Arm Confirmatory Trial (JCOG1009/1010).
Gastroenterology · 7 Aug 2026 · Journal Article
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https://jclub.com.au/a/42567329
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Prospective evaluation of radical surgery for adenocarcinoma of oesophagogastric junction: real-world insights from the CLAEG study.
Gut · 6 Aug 2026 · Multicenter Study
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https://jclub.com.au/a/41611521
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