Intracellular zinc directly inhibits the sperm-specific Slo3 potassium channel by up to micromolar concentrations, with slow dissociation dynamics, affecting sperm capacitation.
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Ion channel regulation and function
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Ca V 2.1 calcium-dependent facilitation is essential for reliable auditory information transfer, with a 37% reduction in postsynaptic firing precision when absent.
- Open access
Spatial proteomics reveals FXYD6 as a dual-site protein at the neuromuscular junction in the diaphragm, with significant enrichment in type IIa fibers.
- Open access
LRRC8A/D heteromeric channels are activated by cell swelling and modulated by sybodies, with a specific structure of four A and two D subunits revealing key conformational states.
- Open access
Mutations in the intracellular subdomain of LRRC8A cause constitutive activation of VRAC channels, highlighting its role as a key regulatory hub.
- Open access
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PRRT2 enhances Nav channel slow inactivation and delays recovery, affecting neuronal excitability from zebrafish to humans.
- Open access
Lamprey KCNE0, an early-diverging KCNE family member, induces constitutive KCNQ1 activity, highlighting its unique role in vertebrate ion channel regulation.
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ABHD6 accelerates deactivation and desensitization of TARP γ-2-containing AMPA receptors, influencing synaptic response timing in the mammalian brain.
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Sub-millivolt voltage imaging uncovers gap junction-mediated bioelectric contact inhibition, showing electrical stability increases with network size and coupling.
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Cryo-EM reveals the human GPR30 bicarbonate receptor structure at 3.15 Å, identifying key residues for bicarbonate binding and activation.
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Parallelized spike sorting pipeline achieves faster, scalable, and reproducible analysis of large-scale electrophysiology data, outperforming previous algorithms like Kilosort2.5.
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