Iron Metabolism and Disorders
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KDIGO 2026 guidelines recommend intravenous iron over oral iron and ESA as the first-line treatment for anemia in CKD, with a target hemoglobin below 11.5 g/dL.
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NINJ2 maintains lysosomal membrane integrity to prevent ferroptosis, with loss increasing susceptibility by 2.5-fold in cell models.
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Elevated blood-brain barrier permeability in sickle cell disease correlates with microstructural brain injury, with 79 plasma proteins linked to systemic pathways influencing BBB disruption.
Maternal vitamin B12 deprivation increases offspring obesity by reducing early colonization of Bifidobacterium pseudolongum during lactation.
Mitochondrial haem scarcity is detected by an ancient OMA1-DELE1 pathway that regulates translation during erythroid development, conserved across species including invertebrates.
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