Metabolic profiling reveals 269 tissue-specific metabolites, with 230 upregulated in root-associated endophytes of Thymus vulgaris, highlighting distinct chemical diversity.
Microbial Natural Products and Biosynthesis
Moving in bioRxiv, Applied and environmental microbiology, Fungal Biology, Journal of bacteriology, mBio, Plant Physiology and Biochemistry, Environmental microbiology, mSystems.
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Latest in Microbial Natural Products and Biosynthesis
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A PEG-mediated protoplast transformation system was successfully developed for Mycena purpureofusca, achieving a stable transformation frequency of 4.3% with 8.90×10^6 protoplasts/mL yield.
A phosphoethanolamine transferase gene from goose fecal microbiome confers high-level colistin resistance in E. coli, highlighting environmental reservoirs of resistance genes.
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Optimized fermentation of Bacillus altitudinis AS19 increased siderophore yield over twofold, enhancing its antifungal activity against Candida albicans.
- Open access
WhiG homologs in Actinomycetota have diverged into two clades, with one regulating flagellar biosynthesis and the other controlling sporulation and diverse processes, driven by c-di-GMP.
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Mutational analysis reveals key base pair requirements for NrdR binding in prokaryotic genomes, enabling precise identification of regulatory sites.
- Open access
Growth-coupled biosynthesis in Pseudomonas putida achieves gram-scale xanthommatin production by linking pigment synthesis to C1 metabolism, reaching significant bioproduction levels.
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Bacillus velezensis ES-120 simultaneously suppresses soil-borne pathogens and promotes plant growth through distinct metabolites, offering a dual-function bioinoculant for sustainable agriculture.
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Disrupted microbiomes amplify temperature-induced respiration increases in Rowella lancifera sponges under simulated marine heatwaves.
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A condensation-independent transacylation mechanism in trans-AT PKSs enables intramodular polyketide chain translocation without decarboxylation, involving KS 0 acting as a transacylase.
Components of the Clp complex are essential for sporangium formation and dehiscence in Actinoplanes missouriensis, with the clpX gene affecting spore release by over three orders of magnitude.
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Fungal endophytes produce alkaloids that alleviate the growth-defense trade-off in plants, with AR37 strains increasing alkaloid levels and plant resistance.
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Pumicyclin A, a novel circular bacteriocin from Bacillus pumilus, exhibits broad-spectrum activity against gram-positive bacteria, including Listeria monocytogenes and B. cereus, with a 6,218 Da mature peptide.
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