The Second Universal Definition of Heart Failure (2026) standardizes classification into reduced, preserved, and improved ejection fraction categories, moving beyond rigid cutoffs.
- 5 cites
Heart Failure Treatment and Management
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Higher heart rates above 50 bpm in stable post-myocardial infarction patients are linked to increased adverse cardiovascular events and mortality, even in the modern reperfusion era.
Robust real-world evidence is essential to optimize GLP-1 receptor agonist use and inform policy decisions amid expanding indications and diverse populations.
- Open access
- 1 cites
Combination heart failure therapies significantly lower systolic blood pressure by up to 9.2 mmHg in HFrEF patients and around 5 mmHg in HFmrEF/HFpEF, with manageable effects on kidney function and potassium levels.
Pulmonary-artery denervation reduces clinical worsening by nearly 50% in patients with heart failure-related pulmonary hypertension compared to medical therapy alone.
The Second Universal Definition of Heart Failure (2026) standardizes classification into reduced, preserved, and improved ejection fraction categories, moving beyond rigid cutoffs.
- 5 cites
Perinatal heart failure affects up to 2% of women, yet its definition, diagnosis, and management remain unclear, risking adverse maternal outcomes.
- Open access
Finerenone slows kidney function decline and reduces cardiovascular and kidney events in adults with CKD without diabetes, with a significant eGFR preservation over 32 months.
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