Distinct tau polymorphs in Alzheimer’s, PSP, and DLB associate with unique protein networks, with 493 high-confidence interactors revealing disease-specific patterns.
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Parkinson's Disease Mechanisms and Treatments
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The G2019S mutation in LRRK2 enhances NADPH oxidase-2 activity in neutrophils, improving bacterial infection control in mice by 2- to 3-fold.
Cortical α-synuclein pathology causes neuronal hypoactivity and circuit changes without impairing visuoperceptual function in a mouse model of early Lewy body dementia.
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Lrrk2 loss disrupts BDNF-dependent synaptic modulation and actin cytoskeleton dynamics, revealing a key pathway in Parkinson's disease pathophysiology.
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