Cerebrospinal Fluid Inflammation in Prodromal Parkinson's Disease

bioRxiv · 12 Nov 2026 · Preprint · Open access

Yasumizu, Deerhake + 21 more

The abstract is read at the publisher; the summary is JClub's.

In cerebrospinal fluid of prodromal Parkinson’s disease participants with RBD, immune cell numbers are increased, especially with lower prodromal PD probability scores linked to time to phenoconversion.

Why it matters: Prodromal PD may start with central inflammation before neurodegeneration, but the specific immune signals and their timing are unclear.
What they did: They combined clinical phenotyping and proteomics with single-cell RNA sequencing of CSF and blood from RBD, PD, and healthy controls, using multiple sclerosis as a comparator.
The result: In those with increased CSF immune cells, macrophages show enhanced TNF, IL-6/JAK/STAT3, and interferon-gamma signaling and predict TNF-associated crosstalk with CD4+ T cells, suggesting stage-specific immune involvement.

AI summary of the abstract · may contain errors · not medical advice · read the paper.

Open access
3 cites

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bioRxiv · 11 Nov 2026 · Preprint
AI summary · may contain errors
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https://jclub.com.au/a/10.64898/2026.03.20.713192
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medRxiv · 9 Nov 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.02.26356952
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PIKfyve inhibition induces LRRK2 activation through phosphatidylinositol 3-phosphate and CASM
bioRxiv · 6 Nov 2026 · Preprint
AI summary · may contain errors
In cells, blocking PIKfyve elevates PI3P and triggers LRRK2 hyperactivation, while adding class III PI3K inhibition suppresses that activation.
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https://jclub.com.au/a/10.64898/2025.12.16.694573
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Cerebrospinal Fluid Inflammation in Prodromal Parkinson's Disease

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Integrating Long-Read Structural Variant Analysis with single-nucleus RNA-seq to Elucidate Gene Expression Effects in Disease

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PIKfyve inhibition induces LRRK2 activation through phosphatidylinositol 3-phosphate and CASM

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