The prevalence of Lewy body pathology across nine international community-based cohorts.

Across nine international community-based brain autopsy cohorts (n = 7309), overall Lewy body pathology prevalence was 27.3%, with neocortical LBP at 8.4%.

• Why it matters: Reported Lewy body pathology prevalence varies widely, and prior estimates often ignore where pathology occurs in the brain and how demographics and co-pathologies relate to clinical status.
• What they did: The study pooled neuropathological, genetic, and clinical data from nine cohorts and calculated region-specific prevalence via meta-analysis, then used mixed-effect logistic regression to test associations with sex, cognitive status, ADNC, and LATE-NC.
• The result: Neocortical LBP was linked to dementia (15%; OR = 4.06, 95% CI 3.24–5.10) and higher odds of ADNC (OR = 2.30, 95% CI 1.88–2.81) and LATE-NC (OR = 2.03, 95% CI 1.69–2.44).

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