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SureCLIP and DrCLIP enable sub-hour protein interaction mapping without genetic manipulation, using reversible crosslinkers DSP and DTBP in cultured cells and wild-type zebrafish.
The iprm-PASEF MALDI-MSI workflow enables confident MS2-based identification and relative quantification of NAD+ and lipid isomers in CD38-/- mouse liver, including a more than 2-fold NAD+ increase.
A proteome-wide gain-of-function screen in HeLa cells mapped 230,000+ gene–drug interactions, showing TAS-102 (Lonsurf) converges on a BCL-2–linked autophagy-endolysosomal survival hub.