Developmental and genetic modulation of evidence integration dynamics in zebrafish sensorimotor decision-making.

Larval Danio rerio develop progressively more persistent, self-reinforcing evidence integration dynamics during early development, as inferred by drift-diffusion modeling of high-throughput behavior.

• Why it matters: It remains unclear how experience, developmental stage, and genotype shape the behavioral algorithms animals use to integrate information over time.
• What they did: The study ran high-throughput behavioral assays in larval zebrafish and fit drift-diffusion models to infer latent integration dynamics across development and in epilepsy- and schizophrenia-linked gene mutation carriers.
• The result: The developmental increase in persistence is reduced in zebrafish with those mutations, enabling scalable, automated, behavior-based modeling to generate testable hypotheses about sensorimotor integration in health and disease.

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