Genomic analysis of early case samples from the 2025 Marburg virus outbreak in Ethiopia.

Seven near-complete Marburg virus genomes from Ethiopia’s first 2025 outbreak show the outbreak lineage is MARV.A.1 and share high nucleotide identity.

• Why it matters: Early outbreak genomes are needed to detect transmission patterns quickly and guide response and preparedness during Marburg virus disease outbreaks.
• What they did: Investigators analyzed seven early-case samples from November 2025, generating near-complete viral genomes and assigning them to the MARV.A.1 clade.
• The result: The high nucleotide identity across the seven genomes suggests human-to-human transmission following a zoonotic spillover, supporting genomic surveillance for outbreak detection and response.

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