Toward planetary microbial systems biology.

Planetary microbial systems biology (PMSB) is proposed as a framework to uncover mechanisms and organizational principles linking Earth’s interconnected microbial systems across matter, space, and time.

• Why it matters: Scientific and geopolitical fragmentation limits integrated understanding of how microbial communities co-evolve with Earth-system drivers, leaving a gap in predictive knowledge of microbiome dynamics.
• What they did: PMSB combines molecular and cellular methods, multi-omics, AI, and transdisciplinary research, federating open data with field observations, experimentation, and modeling.
• The result: This approach is intended to enable predictive understanding of microbiome dynamics across planetary scales, addressing the knowledge gap on co-evolution of life and the Earth-system.

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