Transcriptome of fetal cortex of tree shrew underlying the emergence of outer subventricular zone.

Cell cycle-related genes are already involved in the tree shrew OSVZ across three developmental stages, supporting shared molecular participation in OSVZ development.

• Why it matters: The genetic basis for how the primate outer subventricular zone emerges is unknown, despite its link to cortical expansion and progenitor-rich development.
• What they did: Using laser microdissection, the study profiled gene expression across cortical layers at three developmental stages in the tree shrew, then tested ZNF664 by overexpressing it in the mouse subventricular zone.
• The result: ZNF664 overexpression significantly increased intermediate progenitor proliferation in the mouse subventricular zone, while extracellular matrix-associated pathways appeared unique to the primate OSVZ.

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