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Tumor Microbial Burden Drives Immune Responses through Regulation of Interferon Signaling.
Cancer Discovery · · Journal Article · Open access
Liu, Jang + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
High intratumoral microbial burden in colorectal cancer is linked to interferon pathway regulation and improved outcomes in advanced disease.
- Why it matters: Tumor microbes can shape immune responses and therapy sensitivity, but how microbial load tunes host interferon signaling in specific cancers remains unclear.
- What they did: Across cancers, intratumoral microbial burden was analyzed alongside immune pathway activity and mast cell activation; single-cell sequencing in human CRC identified interferon-related gene induction in microbes-containing cells.
- The result: In rectal MMRd tumors with 100% remission after immune checkpoint blockade, tumor microbes and microbes-containing mast cells increased, and in syngeneic murine MMRd models microbial depletion impaired ICB efficacy by downregulating IFN signaling.
The findingWhy it mattersWhat they didThe result
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