Delivering base editors to the lungs.

Nature materials · 1 Nov 2026 · Journal Article

Cao, Dong

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Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung.
Nature materials · 1 Nov 2026 · Journal Article
AI summary · may contain errors
CHCha-10, an amino acid-derived ionizable lipid, enables inhaled mRNA base editing in the lung, restoring CFTR expression and chloride channel function in cystic fibrosis mice.
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Delivering base editors to the lungs.

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Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung.

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