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E2F1 Drives Endothelial Arterial Programming in Pulmonary Arterial Hypertension

bioRxiv · 7 July 2026 · Preprint · Open access

YI, Tripathi + 7 more

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EBF1 controls an embryonic artery-forming niche that reactivates in pulmonary arterial hypertension
bioRxiv · 1 Nov 2026 · Preprint
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EBF1+ endothelial cells in the adult Aplnr+ gCap compartment reconstitute an embryonic artery-forming niche in pulmonary arterial hypertension, and gCap-specific Ebf1 overexpression drives severe disease.
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- 3 cites
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https://jclub.com.au/a/10.1101/2025.05.02.651303
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iPSC modeling of pulmonary arterial hypertension to uncover pathomechanisms and unrecognized modes of action of sotatercept
bioRxiv · 30 Oct 2026 · Preprint
AI summary · may contain errors
Patient-specific iPSC-derived smooth muscle cells with BMPR2 extracellular- or kinase-domain mutations reproduce Activin A-driven PAH traits, and sotatercept inhibits smooth muscle-to-myofibroblast transition.
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https://jclub.com.au/a/10.64898/2026.03.12.711267
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A GCN1-independent activator of the kinase GCN2.
eLife · 27 Oct 2026 · Journal Article
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Three structurally distinct low-micromolar GCN2 activators were identified in cellulo, including one that activates GCN2 independently of GCN1.
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- 1 cites
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https://jclub.com.au/a/42945303
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