Neutrophil-integrated syncytial CAR macrophages significantly enhance tumor infiltration and therapeutic efficacy, reducing tumor burden and preventing recurrence in mouse models.
Phagocytosis and Immune Regulation
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Necroptosis involves two distinct subtypes, extrinsic and intrinsic, with over 50% of pathways triggered by membrane receptors or intracellular sensors.
Neutrophils limit immunosuppressive macrophage polarization in PDAC liver metastases through trogocytosis, reducing metastatic progression by 50%.
- Open access
ExoU secreted by P. aeruginosa increases lysophosphatidylcholine levels, activating inflammasomes and causing cell death, with significant implications for cystic fibrosis infections.
- Open access
Unconventional protein secretion offers new design principles to enhance rapid control of extracellular protein release in mammalian cells.
- Open access
JUN is essential for the differentiation and maintenance of pro-tumoral monocyte-derived macrophages in tumor development, supporting blood vessel growth and tumor progression.
Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells drives preclinical autoimmunity in mice, linking gut microbes to systemic autoimmune features.
- Open access
Draper-Src-Shark signalling in Drosophila intestinal stem cells detects tissue damage and drives proliferation, essential for midgut regeneration.
- Open access
De novo E-cadherin/catenin complex formation at the basal epithelial surface enables force transmission and efficient apoptotic cell clearance in zebrafish and mice.
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Ibrutinib improves event-free survival in early-stage CLL patients with certain genetic mutations but offers no overall survival benefit across all subgroups.
Engineered macrophages, including CAR-Ms, can reprogram tumor microenvironments and convert "cold" tumors into therapy-responsive niches, with over 100 genetic modifications explored.
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Autophagy inhibition in pancreatic ductal adenocarcinoma (PDAC) enhances macrophage recruitment and tumor cell phagocytosis, with significant effects observed through the CXCL1/2-CXCR2 axis.
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