Nature Immunology · 1 Oct 2026 · Journal Article

Neutrophil-hybrid CAR-macrophages bring double trouble to tumors.

Siwicki, Kubes

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Macrophage-Induced Senescent Cancer-Associated Fibroblasts Promote SASP-Mediated Chemoresistance in Colorectal Cancer.
Cancer Research · 2 Oct 2026 · Journal Article
Macrophage-induced senescent cancer-associated fibroblasts drive 78% chemoresistance in colorectal cancer via SASP factors IL6 and CXCL12.
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IL-1α Expands SLC2A1highSPP1highIFNlow Myeloid Cells to Drive Immune Escape and Malignant Transformation of Precancers.
Cancer Research · 2 Oct 2026 · Journal Article
IL-1α drives expansion of SLC2A1highSPP1highIFNlow myeloid cells, promoting immune escape and malignant transformation in pre-cancerous head and neck lesions.
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Good neighbors make lasting memory.
Nature Immunology · 1 Oct 2026 · Journal Article
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