bioRxiv · 25 Sept 2026 · Preprint · Open access

A temporal threshold in TGF-β signaling separates reversible tissue adaptation from persistent NK cell effector dysfunction

Schmid, Haimerl + 15 more

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HnRNPK restrains memory precursor and plasma cell differentiation to control germinal center B-cell output.
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HnRNPK limits memory B-cell and plasma cell differentiation, maintaining germinal center B-cell output by regulating transcription and metabolism.
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Intratumoral T cell activation kills tumors regardless of T cell specificity.
Nature Immunology · 1 Oct 2026 · Journal Article
Intratumoral T cell activation can eradicate tumors without tumor-specific T cell receptors, relying on paracrine signaling and innate immune responses.
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Monocyte-derived galectin-1(hi) cells provide innate immune help in the generation of functional memory CD8(+) T cells.
Nature Immunology · 1 Oct 2026 · Journal Article
Monocyte-derived galectin-1(hi) cells are essential for generating and maintaining lung tissue-resident memory CD8+ T cells after influenza infection, with over 4 months persistence.
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