KRASG12R pancreatic cancer cells develop resistance to daraxonrasib via EGFR/RASWT signaling, enabling effective trametinib-based therapy and extending patient survival to 40 months.
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Small molecule V20 inhibits SAL phosphatase activity, increasing PAP levels and stress tolerance in Arabidopsis thaliana with 3-fold greater potency than existing inhibitors.
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KRASG12R mutants in pancreatic cancer develop resistance to daraxonrasib via EGFR/RASWT signaling, enabling effective trametinib-based therapy and extended patient survival.
RMC-7977 and daraxonrasib show potent activity against NRAS-mutated melanoma but face resistance mechanisms involving Ppia and Map2k1 mutations.
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