Peptidase Inhibition and Analysis
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Latest in Peptidase Inhibition and Analysis
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Targeting oncomucin-driven immune suppression enhances K-ras(G12D) inhibitor effectiveness in pancreatic cancer, reducing tumor burden and immune checkpoints.
- Open access
- 1 cites
AI-assisted and structure-guided methods have advanced the discovery of PET-degrading enzymes with improved industrial relevance, surpassing traditional bioprospecting.
PTMExplorer enables multi-dimensional visualization of protein PTMs, integrating structural, functional, and disease data across eight model organisms, enhancing biological insights.
- Open access
Loss of FAP-1 causes defective megakaryocyte membrane development, impaired platelet function, and myelofibrosis-like features in mice, with 50% developing severe symptoms.
Proteomic analysis of 267 neuroendocrine carcinomas reveals five subtypes with distinct molecular and therapeutic vulnerabilities, including NAD+ dependency in subtype H.
Lanthivirin BGCs in Actinobacteria produce lanthipeptides that provide potent anti-phage activity, with 6 distinct systems confirmed to inhibit phage DNA replication.
- Open access
- 11 cites
Cryptococcus neoformans relies on surface-associated Dpp4 enzyme for virulence, with deletion reducing pathogenicity and delaying host mortality in animal models.
- Open access
m6A RNA modification acts as a bidirectional regulator of oral epithelial immune responses to Candida albicans, influencing disease severity and potential therapy.
- Open access
The UFSP2-ODR4 complex spatially confines UFM1 deconjugation, preventing neuronal proteostasis disruption and causing severe neurodevelopmental defects when disrupted.
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