Targeted therapies have significantly improved outcomes for specific subgroups of biliary tract cancer, with FGFR2 fusions and IDH1 mutations showing notable response rates.
Fibroblast Growth Factor Research
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SEPTIN7 promotes hepatocellular carcinoma progression and therapy resistance by stabilizing FGFR4 and enhancing its recycling, with knockout suppressing tumor development.
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SDC1-positive cancer-associated fibroblasts universally promote metastasis across multiple cancers via CTGF secretion and FGFR3 activation, with 554 samples analyzed.
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- 3 cites
Erythroid-produced intact FGF23 acts as a paracrine inhibitor of erythropoiesis, contributing to anemia in mice models of iron deficiency and chronic kidney disease.
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- 7 cites
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