AMBRA1 allosterically activates NLRP3 by destabilizing its autoinhibited conformation, promoting inflammatory responses in mouse disease models.
Heme Oxygenase-1 and Carbon Monoxide
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Endogenous carbon monoxide enables cancer-specific drug synthesis using a biocompatible palladium platform, producing cytotoxic agents that suppress tumor growth.
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HDP is essential for mitochondrial protein synthesis in Plasmodium, with knockout disrupting electron flow and causing developmental arrest, independent of hemozoin formation.
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