Research area · week to 3 Oct 2026

Immunodeficiency and Autoimmune Disorders

Moving in Gastroenterology, bioRxiv, Blood, medRxiv, Cellular & molecular immunology, eLife, Gut, Immunity.

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Latest in Immunodeficiency and Autoimmune Disorders

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ABTB1, as an E3 ubiquitin ligase, suppresses Th17 cell differentiation and mitigates autoimmune inflammation by promoting STAT3 ubiquitination and degradation.
Cellular & molecular immunology · 1 Oct 2026 · Journal Article
ABTB1 functions as an E3 ubiquitin ligase that suppresses Th17 cell differentiation by promoting STAT3 degradation, reducing autoimmune inflammation.
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Obexelimab and the Promise of Nondepleting B-Cell Therapy in IgG4-Related Disease.
New England Journal of Medicine · 1 Oct 2026 · Editorial
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Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity.
Nature · 30 Sept 2026 · Journal Article
Loss of histone readers MLLT1 and MLLT3 eliminates all AID-dependent mutagenic activity, highlighting their essential role in locus-specific antibody diversification.
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Respiratory Syncytial Virus infections in immunosuppressed adults <65 years old: a comparative analysis with Influenza and SARS-CoV2
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363680
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DGKα and ζ deficiency causes regulatory T-cell dysregulation, destabilization, and conversion to pathogenic T-follicular helper cells to trigger IgG1-predominant autoimmunity.
eLife · 18 Sept 2026 · Journal Article
DGKα and ζ deficiency in regulatory T cells causes their destabilization and conversion to pathogenic Tfh cells, triggering IgG1-predominant autoimmunity.
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Humoral correlate of vaccine-mediated protection from tuberculosis identified in humans and non-human primates
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.12.05.627012
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Primary Immunodeficiencies Masquerading as Inflammatory Bowel Diseases.
Gastroenterology · 1 Sept 2026 · Journal Article
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Bridging Genetics and Bedside Decisions in Inflammatory Bowel Disease: Utility Metrics for Susceptibility Polygenic Scores.
Gastroenterology · 1 Sept 2026 · Letter
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Effectiveness of Risankizumab After Ustekinumab Failure in Crohn's Disease: A Multicenter Retrospective Cohort Study.
Gastroenterology · 1 Sept 2026 · Journal Article
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Reply.
Gastroenterology · 1 Sept 2026 · Letter
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Ibrutinib for early-stage CLL: genetic risk factors and treatment outcome in the GCLLSG CLL12 trial.
Blood · 27 Aug 2026 · Clinical Trial, Phase III
Ibrutinib improves event-free survival in early-stage CLL patients with certain genetic mutations but offers no overall survival benefit across all subgroups.
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Multi-kingdom signatures of the gut microbiome in Lynch syndrome: a prospective model for colorectal cancer evolution.
Gut · 25 Aug 2026 · Letter
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https://jclub.com.au/a/42642216
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Novel Strategies to Colorectal Cancer Screening for PMS2-Associated Lynch Syndrome Carriers.
Gastroenterology · 20 Aug 2026 · Journal Article
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Ethambutol resistance preceding macrolide resistance in Mycobacterium avium complex pulmonary disease: a retrospective longitudinal study and in vitro analysis
medRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.12.26360314
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How I utilize somatic alterations in the diagnosis, risk stratification, and therapy of hypocellular bone marrow failure.
Blood · 13 Aug 2026 · Review
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Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis
bioRxiv · 13 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.23.713554
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Interleukin 23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity.
Immunity · 11 Aug 2026 · Journal Article
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