Five-year survival rates with neoadjuvant immune checkpoint inhibitors reach up to 87.5% in melanoma, significantly outperforming targeted therapies and combination regimens.
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Melanoma and MAPK Pathways
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MutationProjector, a cancer genotype foundation model, accurately predicts therapeutic resistance and sensitivity across multiple cancer types, surpassing existing methods in all tested contexts.
- Open access
A pediatric patient-derived xenograft (PDX) program created 388 models across 40+ diagnoses, including ultra-rare tumors, enabling detailed cancer biology and therapy studies.
Single-cell technologies reveal how genotypes and phenotypes co-evolve in human tissues, uncovering mutant-specific traits and therapeutic vulnerabilities in cancer.
Spatial analysis uncovers that melanoma transition involves a 3-fold increase in proliferation, metabolic changes, and microenvironment remodeling in nevus-associated melanomas.
DYP688, an antibody-drug conjugate targeting PMEL with a Gq/11 inhibitor payload, shows promising activity in GNAQ/GNA11-mutant melanomas with a 19.7% response rate.
- Open access
Small-molecule inhibitors targeting RAS/RAF disrupt allosteric RAF conformation, effectively treating diverse RAS-driven cancers with a broad-spectrum approach.
- Open access
NtA motif-driven asymmetric BRAF dimerization activates MEK1 phosphorylation, revealing a structural basis for BRAF's role in cancer signaling.
- Open access
- 1 cites
RMC-7977 and daraxonrasib show potent activity against NRAS-mutated melanoma but face resistance mechanisms involving Ppia and Map2k1 mutations.
- Open access
Reduced IQGAP2 expression promotes ESCC cell proliferation by activating the MEK/ERK MAPK pathway, with a significant decrease observed in tumor tissues from patients.
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Next-generation cancer models reveal 147 new gene dependencies across 10 tumor types, expanding the Cancer Dependency Map beyond traditional cell lines.
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