Cell Reports · 22 Sept 2026 · Journal Article · Open access

Mechanistic modeling reveals a configurable AP-1 network governing cell-state heterogeneity and adaptive plasticity in melanoma cells.

Degefu, Bujnowska + more

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Five-year survival with neoadjuvant therapy in melanoma: updated pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC).
Nature Medicine · 1 Oct 2026 · Journal Article
Five-year survival rates with neoadjuvant immune checkpoint inhibitors reach up to 87.5% in melanoma, significantly outperforming targeted therapies and combination regimens.
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A Foundation Model of Cancer Genotype Enables Precise Predictions of Therapeutic Response.
Cancer Discovery · 1 Oct 2026 · Journal Article
MutationProjector, a cancer genotype foundation model, accurately predicts therapeutic resistance and sensitivity across multiple cancer types, surpassing existing methods in all tested contexts.
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A Clinically Integrated Pediatric Patient-Derived Xenograft Program Enables Evaluation of Cohort and Patient-Specific Biology and Therapeutic Strategies.
Cancer Research · 15 Sept 2026 · Journal Article
A pediatric patient-derived xenograft (PDX) program created 388 models across 40+ diagnoses, including ultra-rare tumors, enabling detailed cancer biology and therapy studies.
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