Reg-EXTL3 axis promotes nerve-cancer interactions in pancreatic ductal adenocarcinoma, with silencing reducing tumor progression and pain in mice.
- 3 cites
TGF-β signaling in diseases
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Reg-EXTL3 axis promotes nerve-cancer interactions in pancreatic ductal adenocarcinoma, with silencing reducing tumor progression and pain in mice.
- 3 cites
TIF1γ is essential for maintaining regulatory T cell stability by restraining β-catenin signaling, preventing inflammatory reprogramming during immune challenges.
PCBP2 enhances miR-93-5p-mediated repression of GDF11, a tumor suppressor, promoting proliferation and invasion in hepatocellular carcinoma cells.
- Open access
GDF15-driven remodeling of the liver microenvironment promotes uveal melanoma metastasis, with silencing of GDF15 reducing metastatic growth in models.
- Open access
Cryo-EM structure reveals how LTBP1 binding modulates TGFβ latency and activation, highlighting a hydrophobic interface crucial for complex formation and activity.
- Open access
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