Force Microscopy Techniques and Applications

AI summary · may contain errors

Pro-inflammatory primary human macrophages show lower elastic modulus (E = 458.8 {+/-} 179.9 Pa) and higher dissipation than anti-inflammatory macrophages.

AI summary · may contain errors

A four-variable mechanoadaptive model predicts distinct focal-adhesion modes across ECM stiffness, including a stable oscillatory mode, with adhesion selection depending on stiffness history.

AI summary · may contain errors

Glycerosomes-phosphatidylcholine boundary layers achieve a friction coefficient as low as 10 - 5 at 15.6 MPa, a 20-fold reduction versus conventional PC liposomes.

AI summary · may contain errors

Atomic force microscopy drives structural inversion of individual bowl-shaped sumanene molecules on gold with a net energy cost significantly below the theoretical activation energy.

AI summary · may contain errors

Localized mechanical perturbations in 3D epithelial tissues are linked to cytoskeletal remodelling while preserving tissue polarity, with sub-cellular force patterns at the cell–bead interface.

AI summary · may contain errors

Concurrent cis engagement of CD3γϵ and CD3δϵ with TCRβ forms a stronger, longer-lasting trimolecular catch bond than the sum of two dimeric bonds.

AI summary · may contain errors

Confinement force microscopy reveals that cells respond to spatial confinement with a two-phase stress increase involving passive compression and active contractility.

AI summary · may contain errors

PilU is identified as a second type IV pilus retraction motor in Myxococcus xanthus, and pilU frameshift or deletion abolishes S-motility while preserving pilus assembly and EPS production.