Research area · week to 3 Oct 2026

Cardiomyopathy and Myosin Studies

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Nuclear type I myosins actively support nucleolar and nuclear structure and function.
Genes & Development · 1 Oct 2026 · Journal Article
Nuclear type I myosins are essential for maintaining nuclear structure and function, with depletion causing genome disorganization and nucleolar disruption.
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https://jclub.com.au/a/42562576
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Latest in Cardiomyopathy and Myosin Studies

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KLHL40 gene replacement therapy in severe nemaline myopathy improves survival and skeletal muscle function in a preclinical mouse model
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.753846
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Missense LMNA Variant Compromises Nuclear Integrity and Sarcomeric Remodeling in Dilated Cardiomyopathy
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.753175
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Cryo-electron tomography sheds light on the largest protein in the Trypanosoma brucei tripartite attachment complex
bioRxiv · 19 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2023.03.06.531305
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Profilin promotes lamellipodium protrusion by tuning the antagonistic activities of capping protein and VASP.
Nature Communications · 16 Sept 2026 · Journal Article
Profilin enhances lamellipodium protrusion by regulating the balance between capping protein and VASP, crucial for actin network formation in cell migration.
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https://jclub.com.au/a/42749745
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CFM: confinement force microscopy-a dynamic, precise and stable microconfiner for traction force microscopy in spatial confinement.
Nature Methods · 14 Sept 2026 · Journal Article
Confinement force microscopy reveals two-phase cellular responses to dynamic spatial confinement, with a 2-fold increase in traction forces during active stress buildup.
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https://jclub.com.au/a/42736361
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Sarcomere dynamic instability and stochastic heterogeneity drive robust cardiomyocyte contraction.
eLife · 14 Sept 2026 · Journal Article
Stochastic heterogeneity and dynamic instability in sarcomeres enable robust cardiomyocyte contraction despite mechanical constraints, with 85 kPa stiffness revealing significant heterogeneity.
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https://jclub.com.au/a/42734122
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Reduced Myonuclear Number Is Accompanied by More Regular Longitudinal Nuclear Positioning During Muscle Growth
bioRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.05.722961
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Motor Occupancy Defines Emergent Mechanical States in Cardiac Myosin Ensembles
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.17.739215
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The effects of muscle fibre type distribution on gait biomechanics: A predictive simulation study
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.13.718234
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Zasp52's differentially expressed intrinsically disordered region confers thin filament stability at the Z-disc.
eLife · 27 Aug 2026 · Journal Article
Zasp52's intrinsically disordered region is essential for thin filament stability at the Z-disc in Drosophila muscle, with deletion causing flightlessness and structural defects.
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https://jclub.com.au/a/42657781
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Compressive force from the nuclear envelope in dividing S. pombe alters binding of mitotic spindle proteins and regulates microtubule dynamics
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.15.699759
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Pangenomes aid accurate detection of large insertions and deletions from targeted sequencing: the case of cardiomyopathies.
Genome Medicine · 26 Aug 2026 · Journal Article
Pangenome-based workflow GRAF achieves higher accuracy (F1 0.86) in detecting large pathogenic variants (≥20 bp) from targeted sequencing in cardiomyopathy cases.
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https://jclub.com.au/a/42723105
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Association between sarcopenia and the risk of diabetic cardiomyopathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort study.
Frontiers in Genetics · 25 Aug 2026 · Journal Article
Sarcopenia independently increases the risk of diabetic cardiomyopathy by 2.25 times in patients with type 2 diabetes mellitus.
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https://jclub.com.au/a/42708081
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Deep Learning-Based Single-View Echocardiographic Analysis for Prediction of Left Ventricular Outflow Tract Gradient Elevation After Transcatheter Aortic Valve Replacement
medRxiv · 24 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.27.26349567
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Comparative electrostatic mapping of ATP synthase reveals species-dependent axial asymmetry
bioRxiv · 22 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.14.711807
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Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy.
eLife · 17 Aug 2026 · Journal Article
Second harmonic-generation microscopy reveals that hypertrophic cardiomyopathy-associated R403Q MYH7 mutation increases the myosin ON state fraction in cardiac tissue by approximately 20%.
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https://jclub.com.au/a/42606952
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Histone lysine demethylase inhibition is a disease-modifying therapy for hypertrophic cardiomyopathy
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.07.743611
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Alternative Splicing of TPM1 Mediated by SRPK3 Drives Cardiac Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction.
Circulation · 11 Aug 2026 · Journal Article
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https://jclub.com.au/a/42261667
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Cardiac defects in spinal muscular atrophy and the role of SMN in cardiomyocyte homeostasis
bioRxiv · 9 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.20.713246
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Obstructive Hypertrophic Cardiomyopathy.
New England Journal of Medicine · 6 Aug 2026 · Case Reports
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https://jclub.com.au/a/42544997
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Structural basis for alpha-actinin inhibition of cooperative cofilin binding to actin filaments
bioRxiv · 5 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.16.688667
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