Research area · week to 3 Oct 2026

Pancreatitis Pathology and Treatment

Moving in Gastroenterology, Nature reviews. Gastroenterology & hepatology.

Moved this week: 2

Rebuilt 3 October 2026 at 4:07 pm AEST

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Conceptual framework and expert guidance on intrapancreatic fat deposition: the Melbourne consensus.
Nature reviews. Gastroenterology & hepatology · 16 July 2026 · Review
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Immediate or On-Demand Endoscopic Necrosectomy for Necrotizing Pancreatitis: A Randomized Controlled Trial (WONDER-01)
Gastroenterology · 1 July 2026
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https://jclub.com.au/a/10.1053/j.gastro.2026.01.034
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Asynchronous Evolution of Epithelium and Stroma Differentiates Precursor Lesions from Pancreatic Cancer.
Cancer Discovery · 1 Oct 2026 · Journal Article
Asynchronous evolution of epithelial and stromal components distinguishes pancreatic cancer from precursor lesions, with stromal reprogramming being a key differentiator.
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A Clinical Perspective on Comparative Models of Pancreatic Cyst Surveillance.
Gastroenterology · 1 Oct 2026 · Letter
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Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport.
Gastroenterology · 1 Oct 2026 · Journal Article
Up-regulation of CLDN2 during pancreatitis enhances ductal fluid transport and reduces disease severity, with knockout mice experiencing more severe pancreatitis.
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Chronic Pancreatitis: Mechanisms of Inflammation, Pathways of Progression and Emerging Therapeutic Strategies.
Gastroenterology · 1 Oct 2026 · Review
Chronic pancreatitis involves progressive inflammation and fibrosis, with early-stage mechanisms and biomarkers remaining poorly understood, hindering disease-modifying treatments.
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Gut complement C1q and C3 interact with Clostridioides difficile spores via CdeM and contribute to pathogenesis.
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.753972
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Pancreatic ductal adenocarcinoma: The Vision of Heracles.
Cancer Cell · 14 Sept 2026 · Journal Article
Targeting multiple overlooked factors, the Heracles Protocol offers a comprehensive approach to make pancreatic ductal adenocarcinoma more treatable.
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The metabolic road from α-cells to β-cells.
Nature Chemical Biology · 9 Sept 2026 · Journal Article
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Pharmacological trials of early intervention in predicted severe acute pancreatitis: implications for therapeutic window and core outcome set.
Gut · 7 Sept 2026 · Letter
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Multi-stromal organoid co-culture modelling reveals epithelial-fibroblast heterogeneity in pancreatic cancer and pancreatitis.
Nature Cell Biology · 2 Sept 2026 · Journal Article
Distinct epithelial and fibroblast features in pancreatitis and PDAC are revealed through multi-stromal organoid co-cultures, highlighting disease-specific heterogeneity.
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Understanding development and cellular plasticity in the pancreas in health and disease.
Nature reviews. Gastroenterology & hepatology · 1 Sept 2026 · Review
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Pancreatic Duct Stenting and Interpretation of the Endoscopic Retrograde Cholangiopancreatography Comparator Arm in Malignant Distal Biliary Obstruction.
Gastroenterology · 1 Sept 2026 · Letter
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Endoscopic Ultrasound-Guided Choledochoduodenostomy Versus Endoscopic Retrograde Cholangiopancreatography for the Primary Prevention of Pancreatitis: An Unfair Comparison.
Gastroenterology · 1 Sept 2026 · Letter
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ENPP1 as a Risk-Stratification Biomarker to Inform Selective Surveillance in Chronic Pancreatitis.
Gastroenterology · 1 Sept 2026 · Letter
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Beyond Pancreatitis: What Primary Endoscopic Ultrasound-Guided Choledochoduodenostomy Means for Surgery and Patient-Centered Outcomes.
Gastroenterology · 1 Sept 2026 · Letter
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KRAS-G12D inhibitor HRS-4642 plus chemotherapy in advanced KRAS(G12D)-mutant pancreatic cancer: a phase 1b/2 trial.
Nature Medicine · 1 Sept 2026 · Clinical Trial, Phase I
HRS-4642 combined with chemotherapy achieves a 63.3% objective response rate in advanced KRAS(G12D)-mutant pancreatic cancer, showing promising antitumor activity.
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Clinical Outcomes in Patients With Worrisome and High-Risk Pancreatic Cysts: A Prospective Cohort Study.
Gastroenterology · 20 Aug 2026 · Journal Article
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Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease.
Gut · 18 Aug 2026 · Journal Article
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https://jclub.com.au/a/42613169
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Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis.
Cell Stem Cell · 6 Aug 2026 · Journal Article
Patient-derived organoids reveal widespread CFTR dysfunction in half of chronic pancreatitis cases, including those with wild-type CFTR, and respond to CFTR modulators.
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Evaluating NGS variant callers in a challenging genomic context with a focus on the PRSS1-PRSS2 locus for hereditary pancreatitis.
Gut · 6 Aug 2026 · Letter
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