High-risk rhabdomyosarcomas share a common neural-like cell state, regardless of FOXO1 fusion status, revealing a convergent transcriptional phenotype in lethal cases.
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Sarcoma Diagnosis and Treatment
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A pediatric patient-derived xenograft (PDX) program created 388 models across 40+ diagnoses, including ultra-rare tumors, enabling detailed cancer biology and therapy studies.
BRD9 degradation enhances GBAF chromatin remodeling activity in synovial sarcoma, undermining therapeutic efforts with minimal impact on tumor proliferation.
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IL1RAP antibody-drug conjugates effectively target primary and metastatic tumors in multiple oncofusion-driven cancers, causing tumor regression and reducing metastasis.
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Immunosuppressive tumor microenvironment remodeling in osteosarcoma increases pathological fracture risk by disrupting bone metabolism, with a significant impact on prognosis.
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Chronic stress activates a brain-bone marrow axis that promotes glioblastoma progression by rewiring monocyte differentiation toward pro-tumorigenic macrophages.
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