Research area · week to 3 Oct 2026

Meta-analysis and systematic reviews

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Reproducibility in biomedical research.
Nature Medicine · 29 Sept 2026 · Review
Reproducibility in biomedical research remains inconsistent despite its critical role in ensuring scientific credibility and public trust.
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A pre-registered prospective study of large language models predicting late-breaking cardiovascular trial results at ESC Congress 2026
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.26363773
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Challenges in the Computational Reproducibility of Linear Regression Analyses: An Empirical Study
medRxiv · 6 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.07.26350286
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Study Design Indexing in Transition: A Focused Comparison of manual NLM Indexing vs. Transformer-based Automated Models
medRxiv · 5 Sept 2026 · Preprint
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Secondary use and scholarly impact of a portfolio of clinical trials with shared individual participant level data: cross sectional study.
BMJ · 2 Sept 2026 · Journal Article
Most clinical trials with shared individual participant data (IPD) produced secondary publications, with external investigators contributing nearly 18% of these, increasing over time.
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Sizing up the benefits of clinical trial data sharing.
BMJ · 2 Sept 2026 · Editorial
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In Search of Ethical Procedures for LLM-Assisted Systematic Review Production: A Proof-of-Concept Evaluation of Selected Review Components
medRxiv · 2 Sept 2026 · Preprint
LLMs can effectively assist in specific, well-defined tasks within systematic review processes, achieving up to 86.2% agreement with human decisions when criteria are carefully reworded.
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https://jclub.com.au/a/10.64898/2026.02.18.26346559
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Strengthening the Reporting of Observational Studies in Epidemiology Enhanced Prevalence and Incidence Criteria (STROBE EPIC): An Extension of the STROBE Statement.
Annals of Internal Medicine · 1 Sept 2026 · Journal Article
STROBE EPIC provides a comprehensive 47-item checklist to improve reporting of prevalence and incidence studies in epidemiology, covering all disease types.
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Trials Terminated Early-When Is Enough, Enough?: Clinical Trials in Context.
JAMA · 1 Sept 2026 · Journal Article
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SPIRIT-CONSORT-ELM: Element-Level Assessment of Randomized Controlled Trial Reporting Using Large Language Models
medRxiv · 28 Aug 2026 · Preprint
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Discovery Stack Pilot Demonstrates the Feasibility and Outcomes of a Scientist-Designed Peer-Review Model That Separates Quality and Impact
bioRxiv · 16 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.31.685758
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Making Broad Evidence Synthesis Feasible: An LLM Screening Agent for Meta-Analyses Applied To Suicide Prevention
medRxiv · 14 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.12.26360335
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Evaluating the applicability of replication success metrics in animal-to-human translation: A simulation study.
eLife · 7 Aug 2026 · Journal Article
Most replication success metrics, except meta-analysis and Bayes factor, become liberal with increasing heterogeneity, limiting their reliability in animal-to-human translation assessment.
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An Empirical Assessment of Inferential Reproducibility of Linear Regression in Health and Biomedical Research Papers
medRxiv · 7 Aug 2026 · Preprint
Only 3 out of 14 health research papers using linear regression achieved inferential reproducibility despite similar data and models.
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Availability of clinical trial individual patient data in the BMJ before and after adoption of a stringent data-sharing policy, compared with recent rates at other major medical journals
medRxiv · 7 Aug 2026 · Preprint
Open sharing of individual patient data in BMJ trials increased from 0% to 58% after the 2024 policy change, surpassing rates in other major medical journals.
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- 4 cites
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https://jclub.com.au/a/10.64898/2026.05.15.26353284
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TrialScout links published results to trial registrations using a large language model
medRxiv · 7 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.15.26348383
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Trials Terminated Early: When Is Enough, Enough?
JAMA · 5 Aug 2026 · Journal Article
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