Platelet-derived serotonin activates an epigenetic pathway involving TGM2 and H3Q5Ser to promote macrophage alternative activation in airway inflammation, with 50% reduction in disease severity when inhibited.
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Iron-dependent, protease-independent activation of gasdermin D drives IL-33 release and airway inflammation in allergic diseases, with a key role for ferritinophagy and iron chaperones.
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