The abstract is read at the publisher; the summary is JClub's.
CP variant lacking both functional metal-binding sites (ΔΔ) induces coculture transcriptomic changes in both Pseudomonas aeruginosa and Staphylococcus aureus, linked to reduced alkylquinolone production.
- Why it matters: Calprotectin’s metal-independent effects on polymicrobial interactions are not well defined, despite evidence that its protein scaffold can alter pathogen dynamics without metal sequestration.
- What they did: Using dual-species transcriptomics, the study compared ΔΔ-treated cocultures and measured quorum sensing and alkylquinolone outputs, including C4-homoserine lactone and 2-heptyl-4-hydroxyquinoline N-oxide.
- The result: ΔΔ attenuated C4-homoserine lactone and the anti-staphylococcal alkylquinolone metabolite, and AQ biosynthesis was required for ΔΔ to alter membrane remodeling gene expression in both species.
The findingWhy it mattersWhat they didThe result
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