Industrialization drives convergent microbiome and host physiological shifts in the human metaorganism.

Industrialization is associated with homogenized gut microbial compositions, reduced microbial diversity, and lower community stability in the Global Microbiome Conservancy cohort, independent of host confounders.

• Why it matters: Industrialization reshapes the human metaorganism, but linking microbiome ecology to host physiological shifts across geography and industrial gradients remains incomplete.
• What they did: Using multivariate data from the Global Microbiome Conservancy cohort—gut microbiome, IgA sequencing, host genotyping, diet, lifestyle, and fecal biomarkers—the study tested host–microbiome interactions across industrialization and geography.
• The result: Industrialization is linked to elevated gut stress markers, increased IgA secretion, and altered IgA–bacteria interaction patterns; disease predictors trained on industrialized populations fail to generalize to less industrialized cohorts.

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