MetabDB: an integrated resource for human metabolic measures, disease associations, and genetic evidence.

MetabDB integrates 16 population-scale metabolomics studies and provides 2663 metabolic measures linked to 3524 diseases/outcomes, 3382 GWAS traits, and 2025 molecular QTL targets.

• Why it matters: Metabolic associations are hard to use because results are dispersed across platforms, phenotype definitions, and analytical formats.
• What they did: The database links variants, genes, and proteins to metabolic measures and disease/trait evidence using variant/QTL associations, fine-mapping, rare-variant or burden tests, colocalization, Mendelian randomization, and population associations.
• The result: By retaining source-reported measure forms and analytical details, MetabDB enables integrated search, browsing, and colocalization to examine gene/protein evidence alongside genomic signals and related disease profiles.

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