Nucleic Acids ResJClub
EVLncRNAs 4.0: an updated database of experimentally validated functional long non-coding RNAs with evidence-grounded AI access.
Nucleic Acids Research · · Journal Article
Zhou, Ji + more
Abstract ↗AI summary
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EVLncRNAs 4.0 expands experimentally validated functional lncRNAs to 7808 (+26%) across 199 species (+23%), adding 2313 diseases (+34%) and 18 380 molecular interactions (+25%).
- Why it matters: Functional lncRNA evidence is scattered and context dependent, making it hard to find experimentally supported roles and interpret them consistently across species and disease settings.
- What they did: The team updated EVLncRNAs 4.0 by indexing 16 581 publications from 15 May 2023 to 15 May 2026, manually screening them and curating 28 757 functional records (+21%).
- The result: Two AI-assisted tools—AI Search and Functional Overview—use retrieval-augmented generation over PMID-linked, evidence-grounded records, with benchmarks showing complete request execution, high retrieval coverage, and fully valid citations.
The findingWhy it mattersWhat they didThe result
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