LoGIC: a cross-species local gene-cluster integrative catalog.

LoGIC is a Local Gene-cluster Integrative Catalog containing 20 306 local gene clusters across 30 representative eukaryotic species, enabling multimodal analysis of clustered homologs.

• Why it matters: Homologous genes that sit near each other in genomic clusters can have compensatory roles, making it hard to infer their functions and relationships without integrated, cross-species context.
• What they did: LoGIC compiles local gene clusters from 30 eukaryotic species and provides cluster genomic features plus tools for within-cluster sequence similarity, species-specific functional preference, and cross-species conservation; for human clusters it adds tissue-wide expression and chromatin Hi-C relationships.
• The result: The catalog supports studies of tandem duplication, paralog functional divergence, lineage-specific gene-family expansion, and evolutionary conservation or remodeling of homologous gene clusters across species.

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