PathoEvo: an interactive single-cell database for exploring disease progression and pathological evolution.

PathoEvo is a disease-progression single-cell/single-nucleus RNA database integrating 7 452 971 cells or nuclei from 981 samples across 59 datasets for 18 diseases.

• Why it matters: Public single-cell datasets are often siloed by study and use inconsistent staging annotations, making cross-stage and cross-dataset comparisons difficult.
• What they did: PathoEvo applies manual curation, unified processing, metadata harmonization, cell-type annotation, and stage mapping, organizing data across 27 progression frameworks.
• The result: Users can explore stage-linked shifts in cellular composition and cell states, sample-level molecular variation, and gene-expression dynamics with structured search across diseases and staging systems.

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