Advancing microbial pangenomics through human pangenomics.

Eukaryotic pangenome tools can be extended to microbial species, but the review finds major gaps in scalability, data quality handling, evolutionary complexity, and benchmarking needs.

• Why it matters: Microbial pangenomics faces computational and biological challenges, yet many current methods were built for population-scale eukaryotic datasets, leaving uncertainty about transferability.
• What they did: The review surveys existing eukaryotic and microbial pangenomic approaches, then evaluates adaptation opportunities and challenges for microbial genomes, focusing on scalability, data quality, evolutionary complexity, and benchmarking.
• The result: It identifies areas where current approaches generalize well and highlights where substantive redesign and redevelopment are needed to support microbial pangenomics.

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