Super-resolution mapping of nuclear stress signaling by probiotic-derived extracellular vesicles in UV-induced skin photodamage.

Lactobacillus plantarum-derived extracellular vesicles preserve organelle integrity and restore native nanoscale architecture after UV-induced photodamage, as shown by super-resolution fluorescence microscopy.

• Why it matters: UV photodamage causes oxidative stress, DNA damage signaling, and chronic inflammation, but the nanoscale mechanism of probiotic extracellular vesicles in skin cells is not well defined.
• What they did: Using super-resolution fluorescence microscopy, the study compared UV-irradiated cells with pre- and posttreatment using L. plantarum extracellular vesicles, tracking reactive oxygen species, DNA damage signaling, and inflammatory activation.
• The result: EV treatment delayed UV-induced PARP-1 activation and nuclear condensate clustering and suppressed NF-κB translocation and downstream inflammatory cytokine expression, supporting stress-signaling modulation and structural homeostasis.

AI summary of the abstract · may contain errors · not medical advice · read the paper.