Augmenting intercellular mitochondrial transfer for tissue repair and rejuvenation.

Mitochondrial transfer is an emerging therapeutic paradigm for restoring cellular function, but clinical translation is limited by insufficient organelle trafficking and poor control of transfer dynamics.

• Why it matters: The approach targets diseases linked to mitochondrial dysfunction, including neurodegeneration, cardiovascular disease, metabolic disorders, skeletal muscle defects, immune dysregulation, and age-associated decline.
• What they did: The review summarizes recent bioengineering advances that enhance donor–recipient connectivity, increase mitochondrial availability, and modulate transfer machinery to improve transfer efficiency and regulation.
• The result: These developments begin to address key barriers, supporting broader therapeutic applications while emphasizing that remaining challenges must be resolved for clinical deployment.

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