XYcellAtlas: a cell-type- and spatial-resolved pan-cancer atlas of sex-biased and Y chromosome loss-associated molecular signatures.

XYcellAtlas integrates single-cell and spatial omics across 6764 patient samples to quantify cell-type-specific somatic loss of the Y chromosome (LOY) frequencies across 18 cancer types.

• Why it matters: Sex disparities and LOY in male malignancies are linked to transcriptional and immune microenvironment remodeling, but a unified, multi-resolution atlas across cancers is lacking.
• What they did: The database aggregates over 25.8 million single cells and one million spatial-transcriptomic spots, and uses random forest classifiers trained on normal tissue datasets to estimate LOY frequencies by cell type.
• The result: It catalogs sex-biased and LOY-associated molecular alterations—differential expression, chromatin peaks, core transcription factors, and functional dysregulatory signatures—enabling multi-omics querying and visualization across malignant cells and the tumor microenvironment.

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